Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S12

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   E   Q   L   T   Q   P   E   S       L   T   V   R   P   G   Q   P   L   T
  AJ274741,IGHV3S12*01, 20-10   TGT GAA CAG CTT ACT CAG CCA GAG TCT ... CTG ACT GTC CGA CCT GGT CAA CCT CTG ACC

  AJ279385,IGHV3S12*02, 32      --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   C   C   Q   V   S   Y   S   V   S   S   Y   E                       T   H
  AJ274741,IGHV3S12*01, 20-10   ATC TGC TGT CAG GTC TCT TAT TCT GTT AGT AGC TAC GAG ... ... ... ... ... ACA CAT

  AJ279385,IGHV3S12*02, 32      --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   N   S   L   E   W   I   G   W   I   D   T   G   D
  AJ274741,IGHV3S12*01, 20-10   TGG ATA AGA CAA CCT GAA GGA AAC TCA CTG GAA TGG ATT GGA TGG ATT GAT ACC GGG GAC

  AJ279385,IGHV3S12*02, 32      --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 Q                   H   L   K   D   S   L   S       S   K   F   S   L   A   V
  AJ274741,IGHV3S12*01, 20-10   CAA ... ... ... ... CAC CTG AAA GAC TCT CTT AGT ... AGT AAA TTC AGT CTT GCC GTT

  AJ279385,IGHV3S12*02, 32      --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---

                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   G   S   S   K   T   V   T   L   Q   G   Q   S   M   Q   P   G   D   S   A
  AJ274741,IGHV3S12*01, 20-10   GAC GGC TCC AGT AAA ACA GTA ACT TTG CAA GGG CAA AGC ATG CAG CCT GGA GAC TCA GCT
                                                                                 N  
  AJ279385,IGHV3S12*02, 32      --- --- --- --- --- --- --- --- --- --- --- --- -A- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   R
  AJ274741,IGHV3S12*01, 20-10   GTG TAT TAC TGT GCC AGA     #c

  AJ279385,IGHV3S12*02, 32      --- --- --- --- --- ---     #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc